PhysiologybioRxivPreprint
Phosphodiesterase type 1 regulates adenosine 2A receptor-associated cAMP signaling at the plasma membrane to increase myocardial contractility
Michael L. Fitch, Maria Alexandria Martins Goncalves, Mary H. Y. Tang…·Grace K. Muller
This study shows PDE1 regulates A2AR-associated cAMP signaling at the sarcolemma to enhance myocardial contractility in healthy and failing hearts.
DOI 10.1101/2025.10.03.680406