Bing Ren

The paper outlines the goals and structure of the 4D Nucleome Project, which aims to map the spatial and temporal dynamics of the genome in human and mouse cells.

HUGIn is a web browser for visualizing Hi-C data from 21 human primary tissues and cell lines to assess chromatin contacts across and specific to tissues or cell lines.

This study shows that MLL3/4 proteins regulate chromatin interactions at enhancers by depositing H3K4me1, which recruits Cohesin to facilitate chromatin looping.

The paper introduces a method combining proximity ligation with chromatin immunoprecipitation and sequencing to map long-range chromatin interactions in eukaryotic cells, showing improved sensitivity and accuracy in mouse embryonic stem cells.