Author

Shi-An A. Chen

Stanford UniversityORCID 0000-0002-9880-9742Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:yeast· 3 Assay:DNA methylation· 2 Research Focus:variant effect prediction· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Hunter B. FraseriD· 3 shared Alexander Kern· 2 shared Roy Moh Lik AngiD· 2 shared Yihua Xie· 2 shared Ah Young LeeiD· 1 shared Andrea LocaliD· 1 shared Bing ReniD· 1 shared Chaochen WangiD· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersGenomics

Hunter B. FraserORCID

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4 papers

Recent·Most cited

Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation

José Aguilar-Rodríguez, Jean C. C. Vila, Shi-An A. Chen, Manuel Razo‐Mejia, Olivia M. Ghosh, Daniel F. Jarosz, Hunter B. Fraser, Dmitri A. Petrov

The paper assesses fitness effects of 9,000 natural variants in yeast signaling pathways, finding that many non-neutral variants show signs of local adaptation.

bioRxiv · Oct 30, 2024 · PreprintEvolutionary Biology

Widespread epistasis among beneficial genetic variants revealed by high-throughput genome editing

Roy Moh Lik Ang, Shi-An A. Chen, Alexander Kern, Yihua Xie, Hunter B. Fraser

Cell Genomics · Feb 28, 2023Peer-reviewedGenomics

Gene-by-environment interactions are pervasive among natural genetic variants

Shi-An A. Chen, Alexander Kern, Roy Moh Lik Ang, Yihua Xie, Hunter B. Fraser

The paper identifies pervasive gene-by-environment interactions among natural genetic variants in yeast using high-throughput genome editing.

Cell Genomics · Feb 28, 2023Peer-reviewedGenomics

Histone H3 Lysine 4 methyltransferases MLL3 and MLL4 Modulate Long-range Chromatin Interactions at Enhancers

Jian Yan, Shi-An A. Chen, Andrea Local, Tristin Liu, Yunjiang Qiu, Ah Young Lee, Inkyung Jung, Sebastian Preißl, Chloe M. Rivera, Chaochen Wang, Haruhiko Ishii, Rongxin Fang, Zhen Ye, Kai Ge, Ming Hu, Bing Ren

This study shows that MLL3/4 proteins regulate chromatin interactions at enhancers by depositing H3K4me1, which recruits Cohesin to facilitate chromatin looping.

bioRxiv · Feb 21, 2017 · PreprintGenomics