Author

Shalini Gupta

Howard Hughes Medical InstituteORCID 0000-0002-5446-7912Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Shalini Gupta1 paper

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:yeast· 1

Frequent Co-Authors

Jeff GellesiD· 2 shared Larry J. FriedmaniD· 2 shared Stephen P. BelliD· 2 shared Audra L. AmasinoiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersMolecular Biology

Jeff GellesORCID

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2 papers

Recent·Most cited

Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2-7 ring closing

Audra L. Amasino, Shalini Gupta, Larry J. Friedman, Jeff Gelles, Stephen P. Bell

The paper investigates how ORC phosphorylation inhibits helicase loading by preventing Mcm2-7 ring closure in budding yeast.

Proceedings of the National Academy of Sciences · Jul 10, 2023Peer-reviewedMolecular Biology

A Helicase-tethered ORC Flip Enables Bidirectional Helicase Loading

Shalini Gupta, Larry J. Friedman, Jeff Gelles, Stephen P. Bell

The paper shows a single ORC molecule can load two oppositely-oriented Mcm2-7 helicases through a coordinated process involving Cdt1 release and ORC rearrangement.

eLife · Dec 9, 2021Peer-reviewedMolecular Biology