Stephen P. Bell

This study identifies suppressor mutations for a lethal ORC ATPase defect in yeast, revealing a link between ORC ATP hydrolysis and transcription.

This paper identifies an Orc6 tethering interaction that enables ORC to switch binding sites during replication origin licensing, showing its role in helicase loading and cell-cycle regulation.

This study reveals a noncanonical GTPase signaling mechanism in budding yeast where Tem1 localization, not its nucleotide state, controls MEN activation by increasing effective concentration for Cdc15 interaction.

This study investigates how changing protein-DNA interactions enable ORC to switch DNA binding sites during replication origin licensing, revealing a stepwise mechanism involving DNA unbending, sliding, and reduced ORC stability.

The paper investigates how ORC phosphorylation inhibits helicase loading by preventing Mcm2-7 ring closure in budding yeast.

The paper shows a single ORC molecule can load two oppositely-oriented Mcm2-7 helicases through a coordinated process involving Cdt1 release and ORC rearrangement.