All-trans retinoic acid-mediated ADAR1 degradation synergizes with PD-1 blockade to suppress pancreatic cancer
Ching-Fei Li, Li‐Yuan Bai, Yongkun Wei, Heng‐Huan Lee, Ri‐Yao Yang, Jun Yao, Huamin Wang, Ying‐Nai Wang, Wei‐Chao Chang, Yi-Chun Shen, Shao‐Chun Wang, Cheng-Wei Chou, Jie Fu, Jianhua Ling, Yu‐Yi Chu, , Mien‐Chie Hung
This study shows that ATRA causes ADAR1 degradation and enhances PD-1 blockade to improve antitumor immunity and survival in pancreatic cancer.
bioRxiv · Oct 20, 2024 · PreprintCancer Biology