N-formylkynurenine but not kynurenine enters a nucleophile-scavenging branch of the immune-regulatory kynurenine pathway
Yongxin Wang, Euphemia Yee Leung, Petr Tomek
The paper shows N-formylkynurenine (NFK) undergoes non-enzymatic deamination to form reactive adducts, distinct from kynurenine (KYN), highlighting a new branch of the kynurenine pathway with implications for immune regulation and protein modification.
Bioorganic Chemistry · Jan 28, 2025Peer-reviewedBiochemistry