Euphemia Yee Leung

N-formylkynurenine but not kynurenine enters a nucleophile-scavenging branch of the immune-regulatory kynurenine pathway

The paper shows N-formylkynurenine (NFK) undergoes non-enzymatic deamination to form reactive adducts, distinct from kynurenine (KYN), highlighting a new branch of the kynurenine pathway with implications for immune regulation and protein modification.

Sensitivity to temozolomide of cell lines derived from brain tumours and melanomas: relationship to MGMT gene expression

The paper assesses temozolomide sensitivity in melanoma and glioblastoma cell lines and finds a strong correlation with MGMT mRNA expression but only partial correlation with MGMT promoter methylation.