FAST RESENSITIZATION OF G PROTEIN-COUPLED RECEPTORS REQUIRESTHEIR PI(4,5)P2-DEPENDENT SORTING INTO AN AP2 POSITIVE COMPARTMENT
Gergő Gulyás, Takashi Baba, Dániel J. Tóth, Asuka Inoue, Tamás Balla
This study shows that GPCRs regain G protein signaling without endocytosis by sorting into an AP2-positive plasma membrane compartment, regulated by PI(4,5)P2 and beta-arrestins.
bioRxiv · Mar 28, 2025 · PreprintBiochemistry