Tamás Balla

Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA

The paper develops a nanobody that selectively blocks EFR3 recruitment of PI4KA by targeting TTC7B, reducing membrane recruitment and PI4P production.

Phosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane

The paper identifies a metabolic connection between PI4P and PA at the plasma membrane, showing how PI4P depletion increases PA levels through PS synthesis and RhoB activation.

FAST RESENSITIZATION OF G PROTEIN-COUPLED RECEPTORS REQUIRESTHEIR PI(4,5)P2-DEPENDENT SORTING INTO AN AP2 POSITIVE COMPARTMENT

This study shows that GPCRs regain G protein signaling without endocytosis by sorting into an AP2-positive plasma membrane compartment, regulated by PI(4,5)P2 and beta-arrestins.

Molecular basis for plasma membrane recruitment of PI4KA by EFR3

The paper reports a cryo-EM structure of EFR3A bound to the PI4KA complex, revealing the molecular mechanism of PI4KA membrane recruitment and its regulation in human disease.