Human salivary amylase gene copy number impacts oral and gut microbiomes
Angela C. Poole, Julia K. Goodrich, Nicholas D. Youngblut, Guillermo G. Luque, Albane Ruaud, Jessica L. Sutter, Jillian L. Waters, Qiaojuan Shi, Mohamed S. El-Hadidi, Lynn M. Johnson, Haim Bar, Daniel H. Huson, James G. Booth, Ruth E. Ley
The paper shows that human AMY1 gene copy number affects oral and gut microbiome composition and function, with low-AMY1 associated with enhanced complex carbohydrate breakdown and high-AMY1 linked to resistant starch fermentation and higher adiposity.
Cell Host & Microbe · Apr 1, 2019Peer-reviewedGenetics