Angela C. Poole

This study examines the relationship between salivary amylase gene copy number, enzyme activity, and type 2 diabetes status, finding a positive association between AMY1 CN and SAA in both T2D and control groups.

The paper shows that human AMY1 gene copy number affects oral and gut microbiome composition and function, with low-AMY1 associated with enhanced complex carbohydrate breakdown and high-AMY1 linked to resistant starch fermentation and higher adiposity.