Enhanced delivery of protein therapeutics with a diphtheria toxin-like platform that evades pre-existing neutralizing immunity
Shivneet K. Gill, Seiji N. Sugiman‐Marangos, Greg L. Beilhartz, E. Mei, Mikko Taipale, Roman A. Melnyk
This paper identifies a diphtheria toxin homolog from Austwickia chelonae that evades pre-existing anti-DT antibodies and shows improved cargo delivery compared to diphtheria toxin.
EMBO Molecular Medicine · Aug 19, 2024Peer-reviewedBiochemistry