Greg L. Beilhartz

Balancing receptor engagement and payload catalytic activity broadens the therapeutic window of immunotoxins

This study shows that reducing the catalytic activity of immunotoxins while balancing receptor engagement improves their selectivity and therapeutic window.

De novo design of potent inhibitors of Clostridioides difficile toxin B

This paper designs potent small protein inhibitors of C. difficile toxin B using deep learning and Rosetta, showing high affinity and stability for potential clinical use.

Enhanced delivery of protein therapeutics with a diphtheria toxin-like platform that evades pre-existing neutralizing immunity

This paper identifies a diphtheria toxin homolog from Austwickia chelonae that evades pre-existing anti-DT antibodies and shows improved cargo delivery compared to diphtheria toxin.

Identification of the C. sordellii lethal toxin receptor elucidates principles of receptor specificity in clostridial toxins

The paper identifies SEMA6A and SEMA6B as receptors for C. sordellii lethal toxin and shows how mutations can switch receptor specificity between related toxins.