Author

Connor J. Cooper

Oak Ridge National LaboratoryORCID 0000-0002-5527-9948Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ankit JoshiiD· 1 shared James A. CarsoniD· 1 shared Jeremy C. SmithiD· 1 shared Jerry M. ParksiD· 1 shared Julie C. MitchelliD· 1 shared Khanh HaiD· 1 shared L. Darryl QuarlesiD· 1 shared Madhulika GuptaiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioinformatics

Ankit JoshiORCID

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2 papers

Recent·Most cited

Structure-Based Design of Small-Molecule Inhibitors of Human Interleukin-6

Ankit Joshi, Zhousheng Xiao, Shreya Suman, Connor J. Cooper, Khanh Ha, Rupesh Agarwal, James A. Carson, L. Darryl Quarles, Jeremy C. Smith, Madhulika Gupta

The paper designs small-molecule inhibitors of hIL-6 using computational screening and validates one compound's inhibitory effect on IL6-induced STAT3 activity.

Molecules · Jul 10, 2025Peer-reviewedBioinformatics

Hotspot coevolution at protein-protein interfaces is a key identifier of native protein complexes

Sambit Kumar Mishra, Connor J. Cooper, Jerry M. Parks, Julie C. Mitchell

This study introduces KFC-E, a scoring function that uses conservation and coevolution of hotspot residues to identify native protein complexes, achieving better performance than alternative methods.

bioRxiv · Jul 10, 2019 · PreprintBioinformatics