BiochemistrybioRxivPreprint
Evolutionary analysis of PINK1 reveals key roles of the N- and C-terminal extensions and TOM20 in folding its kinase domain
Tara Shomali, Simon Veyron, Jean‐François Trempe
This study identifies evolutionary differences in PINK1 orthologues that affect stability and activity, revealing the role of NTE, CTE, and TOM20 in kinase function and pathogenic variants.