Kyle J. Lauersen

Cultivation and physiological characterization of a desert-derived Halospirulina isolate

This paper isolates and characterizes Halospirulina saudiensis from the desert, reports its genome, and shows its potential for producing ketocarotenoids and phycocyanin under saline conditions.

Genome Position Does Not Impact Transgene Expression Efficiency in the Ancient Red Alga Cyanidioschyzon merolae

This study identifies neutral genomic integration sites in Cyanidioschyzon merolae and demonstrates uniform transgene expression across different positions.

Investigating the dynamics of precursor availability for sesquiterpenoid production in the cytoplasm and plastid of Chlamydomonas reinhardtii

This study investigates sesquiterpenoid production in Chlamydomonas reinhardtii by expressing patchoulol synthase in different subcellular compartments and optimizing carbon sources to maximize yield.

Engineered isoprene production from Chlamydomonas reinhardtii using herbicide selection markers and CO2-fed cultivation optimization through multi-parallel photobioreactor headspace gas analysis

This paper engineers isoprene production in Chlamydomonas reinhardtii using herbicide resistance markers and CO2-fed cultivation optimization to generate biomass and isoprene from wastewater.

Elevated carbon dioxide stimulates highly efficient organic-carbon consumption and confectionary-waste valorization under mixotrophy in the unicellular alga Galdieria

This paper investigates how elevated CO2 enhances organic-carbon consumption and confectionery-waste valorization in Galdieria algae under mixotrophy.

Treatment with Metal-Organic Frameworks (MOFs) elicits secondary metabolite accumulation in Aquilaria crassna (Agarwood) callus culture

The paper investigates using metal-organic frameworks (MOFs) to elicit secondary metabolite accumulation in Aquilaria crassna callus cultures, finding that certain MOFs significantly increase metabolite production.

Sustainable in situ extraction of microalgae-derived terpenoids using functionalized silica microparticles

This paper develops a solvent-free method using functionalized silica particles to extract terpenoids from microalgae, showing potential for large-scale applications due to safety and reusability advantages.

A rapid CAT transformation protocol and nuclear transgene expression tools for metabolic engineering in Cyanidioschyzon merolae 10D

This paper introduces a rapid transformation protocol and tools for metabolic engineering in Cyanidioschyzon merolae, demonstrating isoprene production using a synthetic plasmid toolkit.

Compartmentalized sesquiterpenoid biosynthesis and functionalization in the Chlamydomonas reinhardtii plastid

This paper demonstrates the production and functionalization of heterologous sesquiterpenoids in the plastid of Chlamydomonas reinhardtii using STPs and soluble CYPs, achieving up to 80% functionalization and 250-2500 µg L-1 yields.

A green alternative to fragrant agarwood sesquiterpenoid production

This paper develops a sustainable method to produce agarwood-like sesquiterpenoids using synthetic biology in algae, avoiding the need for harvesting endangered trees.

Biocompatible fluorocarbon liquid underlays for in situ extraction of isoprenoids from microbial cultures

The paper demonstrates that synthetic perfluorocarbon liquids can serve as effective physical sinks for isoprenoid metabolites produced by microbial cultures, offering advantages over traditional hydrocarbon solvents.

Synthetic metabolic pathways for photobiological conversion of CO2 into hydrocarbon fuel

This paper engineers synthetic metabolic pathways in photosynthetic microorganisms to convert CO2 into hydrocarbon fuels, achieving up to 19-fold and 8-fold increases in alkane and alkene yields in cyanobacteria and algae, respectively.