Author

Heshadi Primrose Primrose Mandalawatta

University of TasmaniaORCID 0000-0002-5539-7047Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Alex William HewittiD· 1 shared Kirsten A. FairfaxiD· 1 shared Rajendra KCiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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1 shared paperMolecular Biology

Alex William HewittORCID

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1 paper

Recent·Most cited

Exploring Prime Editing strategies for genetic correction of a Ceroid Neuronal Lipofuscinosis type 2 disease causing variant

Heshadi Primrose Primrose Mandalawatta, Rajendra KC, Kirsten A. Fairfax, Alex William Hewitt

This study uses prime editing to correct a common TPP1 mutation in cultured cells and eVLPs, achieving on-target editing efficiencies of up to 27.36% and 12.6% in vivo.

bioRxiv · Oct 2, 2025 · PreprintMolecular Biology