Miharu Maeda

This study shows that phosphorylation and dephosphorylation of TANGO1 and Sec16, regulated by FAM83A/CK1 and phosphatases, maintain functional ER exit sites for secretory protein transport.

The paper introduces SAIYAN, a method to detect small GTPase activation, revealing Sar1 activation at ER exit sites and ERGIC during collagen secretion.

This study shows cTAGE5 enhances Sec23's GAP activity toward Sar1 and is necessary for collagen export from the ER.