The TET-dependent DNA demethylation pathway is the driving force of hematopoiesis
Galina Dvoriantchikova, Michelle Fleishaker, Henry Barreras, Robert B. Levy, Dmitry Ivanov
This study shows that TET-mediated DNA demethylation is essential for hematopoiesis by activating lineage-specific genes in HSPCs, with loss of TET activity causing hematological malignancies.
bioRxiv · May 2, 2026 · PreprintImmunology