ImmunologybioRxivPreprint
The TET-dependent DNA demethylation pathway is the driving force of hematopoiesis
Galina Dvoriantchikova, Michelle Fleishaker, Henry Barreras…·Dmitry Ivanov
This study shows that TET-mediated DNA demethylation is essential for hematopoiesis by activating lineage-specific genes in HSPCs, with loss of TET activity causing hematological malignancies.
DOI 10.64898/2026.04.29.721744