Evolutionary BiologybioRxivPreprint
Thermoregulatory Constraints on Regenerative Competence: Evolutionary Trade-Offs Between Metabolic Homeostasis and Tissue Repair
Daniel Pelaez, Chloe Moulin, Jaelyn Chang, Kendall W. Knechtel
This paper proposes a thermoregulatory theory linking endothermy to reduced regenerative capacity in mammals and birds, suggesting that calcium signaling in thermogenic systems inhibits tissue repair.