BiophysicsbioRxivPreprint
Sphingomyelin-Cholesterol Synergy as a Lipid Chaperone Driving Cytolysin A Pore Formation
Achinta Sannigrahi, Debayani Chakraborty, Rimjhim Moral…·Rahul Roy
This study shows that host sphingomyelin and cholesterol act as a lipid chaperone to facilitate the conformational changes of the bacterial toxin Cytolysin A, enabling pore formation.
DOI 10.64898/2026.01.27.702101