Sphingomyelin-Cholesterol Synergy as a Lipid Chaperone Driving Cytolysin A Pore Formation
Achinta Sannigrahi, Debayani Chakraborty, Rimjhim Moral, Vishwesh Haricharan Rai, Avijeet Kulshrestha, Dibyajyoti Maity, Muhsin Vannan Chalil, K. G. Ayappa, Sandip Paul, Rahul Roy
This study shows that host sphingomyelin and cholesterol act as a lipid chaperone to facilitate the conformational changes of the bacterial toxin Cytolysin A, enabling pore formation.
bioRxiv · Jan 28, 2026 · PreprintBiophysics