MCM10 and SLD-2/RECQL4 jointly activate the CMG helicase during metazoan DNA replication initiation
Remi Sonneville, Cécile Evrin, Jane Wright, He Huang, Yisui Xia, Karim P. M. Labib
The paper shows that MCM10 and SLD-2/RECQL4 are required for helicase activation in metazoan DNA replication, with mutations in these factors linked to human disease.
The EMBO Journal · Sep 28, 2026Peer-reviewedMolecular Biology