Author
University of DundeeORCID 0000-0001-8861-379XUnclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
6 papers
Recent·Most cited
Remi Sonneville, Cécile Evrin, Jane Wright…·Karim P. M. Labib
The paper shows that MCM10 and SLD-2/RECQL4 are required for helicase activation in metazoan DNA replication, with mutations in these factors linked to human disease.
Ryo Fujisawa, Karim P. M. Labib
The paper identifies TTF2 as a regulator that couples TRAIP to Pol epsilon, enabling TRAIP to ubiquitylate the CMG helicase and drive replisome disassembly and MiDAS during mitosis.
Fabrizio Villa, Johanna Ainsworth, Karim P. M. Labib
This study identifies USP37's role in protecting mammalian cells from DNA replication stress by counteracting ubiquitylation of the CMG helicase by CUL2LRR1 and TRAIP.
Cristian Polo Rivera, Tom D Deegan, Karim P. M. Labib
This study shows that CMG helicase disassembly is essential in budding yeast and occurs via two pathways involving ubiquitylation and Rrm3/Pif1 helicases.
Olawale G. Raimi, Hina Ojha, Kenneth Ehses…·Miratul M. K. Muqit
This study identifies TOM20, TOM70, TOM40, and associated subunits as critical for PINK1 activation in a reconstituted yeast system, providing insights for PINK1 activator development.
Ryo Fujisawa, Cristian Polo Rivera, Karim P. M. Labib
The paper shows that UBX proteins lower the ubiquitin threshold for p97-UFD1-NPL4 to unfold substrates, similar to yeast.