Confinement prevents postmenopausal osteoporosis and obesity via nuclear mechanical remodeling
Min Xu, Lei Wang, Weihao Wang, Haoxiang Yang, Hongyuan Jiang
This study shows mechanical confinement of BMSCs on soft substrates prevents PMOP and obesity by enhancing osteogenesis and reducing adipogenesis through nuclear mechanotransduction.
bioRxiv · Dec 16, 2025 · PreprintBiophysics