Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin.
Madhura N. Paranjpe, Valeria I. Marina, Aleksandr A. Grachev, Tinashe P. Maviza, Olga A. Tolicheva, Alena Paleskava, Ilya А. Osterman, Сергиев Петр Владимирович, Andrey L. Konevega, Yury S. Polikanov, Matthieu G. Gagnon
This paper investigates how thermorubin inhibits translation by causing ribosome stalling and affecting tRNA binding and translation elongation.
Nucleic Acids Research · Dec 22, 2022Peer-reviewedMolecular Biology