Xiaomin Yang

This paper develops a dual-layer computational framework to identify therapeutic candidates targeting EV-mediated immune escape in PDAC by integrating gene prioritization and small-molecule design with antibody-like binder models.

The paper examines how multitrophic species interaction networks influence ecosystem multifunctionality and finds that network structure, including niche overlap and linkage density, significantly affects ecosystem function.

V3Cell predicts organoid responses to chemical perturbations using non-invasive bright-field microscopy, creating virtual 3D cell models that mimic real organoids in structure and developmental dynamics.

This study shows that resistance to different WRN inhibitors in MSI-H cancers creates orthogonal vulnerabilities, enabling alternating therapy and mutation-tolerant inhibitor design.