NeurosciencebioRxivPreprint
Inflammasome mediated neuronal-microglial crosstalk: a therapeutic substrate for the familial C9orf72 variant of the frontotemporal dementia/amyotrophic lateral sclerosis
Kyle J. Trageser, Chad Smith, Eun‐Jeong Yang…·Giulio Maria Pasinetti
This study investigates the role of the NLRP3 inflammasome in C9orf72 FTD/ALS pathogenesis, finding that its inhibition improves survival and reduces neurodegeneration.
DOI 10.1101/2022.01.27.478078