Author

Kyle J. Trageser

Icahn School of Medicine at Mount SinaiORCID 0000-0001-9161-0178Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Giulio Maria PasinettiiD· 3 shared Eun‐Jeong YangiD· 2 shared Molly S. EstilliD· 2 shared Tatsunori Oguchi· 2 shared Ava L. ShipmaniD· 1 shared Aya OsmaniD· 1 shared Brian MathewiD· 1 shared Chad SmithiD· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersNeuroscience

Giulio Maria PasinettiORCID

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3 papers

Recent·Most cited

NeuroscienceeLifePeer-reviewedJun 28, 2023

Molecular and cellular similarities in the brain of SARS-CoV-2 and Alzheimer's disease individuals

Elizabeth Griggs, Kyle J. Trageser, Sean X. Naughton…·Giulio Maria Pasinetti

This study compares transcriptional and cellular changes in brain regions of SARS-CoV-2 infected, Alzheimer's disease, and SARS-CoV-2 infected Alzheimer's disease individuals to identify shared neuroinflammatory and blood-brain barrier alterations.

23 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintJun 14, 2022

Dietary polyphenols drive alterations in behavior, transcriptional regulation, and commensal microbiota in models of opioid use.

Aya Osman, Rebecca S. Hofford, Katherine R. Meckel…·Drew D. Kiraly

This study shows dietary polyphenols alter behavior, gene expression, and microbiota in response to morphine, with dose-dependent effects.

DOI 10.1101/2022.06.14.496180

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintJan 27, 2022

Inflammasome mediated neuronal-microglial crosstalk: a therapeutic substrate for the familial C9orf72 variant of the frontotemporal dementia/amyotrophic lateral sclerosis

Kyle J. Trageser, Chad Smith, Eun‐Jeong Yang…·Giulio Maria Pasinetti

This study investigates the role of the NLRP3 inflammasome in C9orf72 FTD/ALS pathogenesis, finding that its inhibition improves survival and reduces neurodegeneration.

DOI 10.1101/2022.01.27.478078

mouseexperimental assay

𝕏 PostBluesky