Inflammasome mediated neuronal-microglial crosstalk: a therapeutic substrate for the familial C9orf72 variant of the frontotemporal dementia/amyotrophic lateral sclerosis
Kyle J. Trageser, Chad Smith, Eun‐Jeong Yang, Ruth Iban‐Arias, Tatsunori Oguchi, Maria Sebastian-Valverde, Umar Haris Iqbal, Henry D. Wu, Molly S. Estill, Md Al Rahim, Urdhva Raval, Francis J. Herman, Yong Jie Zhang, Leonard Petrucelli, Giulio Maria Pasinetti
This study investigates the role of the NLRP3 inflammasome in C9orf72 FTD/ALS pathogenesis, finding that its inhibition improves survival and reduces neurodegeneration.
bioRxiv · Jan 27, 2022 · PreprintNeuroscience