Author

Smitha Sivapragasam

Washington State UniversityORCID 0000-0002-5599-9988Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Organism:yeast· 1

Frequent Co-Authors

Gregory M.K. PooniD· 2 shared John J. WyrickiD· 2 shared Arjan van der VaartiD· 1 shared Jacob S. Antony· 1 shared James Ross TerrelliD· 1 shared Jenna Ulibarri· 1 shared John M. Hinz· 1 shared Marian F. Laughery· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Gregory M.K. PoonORCID

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2 papers

Recent·Most cited

Molecular basis of UV lesion binding and repair inhibition by ETS-family transcription factors

Smitha Sivapragasam, James Ross Terrell, Arjan van der Vaart, Markus W. Germann, Marian F. Laughery, Michaela E. Everly, Shiva P. Adhikari, Patrick J. Hrdlicka, John J. Wyrick, Gregory M.K. Poon

This study investigates how ETS-family transcription factors bind to UV-damaged DNA and inhibit repair, revealing structural and dynamic differences that explain mutation hotspots in melanoma.

Nucleic Acids Research · Jul 17, 2026Peer-reviewedBiochemistry

High-resolution mapping of DNA alkylation damage and base excision repair at yeast transcription factor binding sites

Mingrui Duan, Smitha Sivapragasam, Jacob S. Antony, Jenna Ulibarri, John M. Hinz, Gregory M.K. Poon, John J. Wyrick, Peng Mao

This study maps DNA alkylation damage and base excision repair at yeast transcription factor binding sites, showing TF binding suppresses damage formation and inhibits repair.

eLife · Mar 15, 2022Peer-reviewedGenomics