BioinformaticseLifePeer-reviewed
Identifying Gene Expression Programs of Cell-type Identity and Cellular Activity with Single-Cell RNA-Seq
Dylan Kotliar, Adrian Veres, M. Aurel Nagy…·Pardis Christine Sabeti
This paper introduces cNMF, a matrix factorization method to disentangle cell-type identity and activity programs from scRNA-Seq data, showing it improves cell type hierarchy and identifies novel activity programs.