M. Aurel Nagy

This study delivers GJB2 specifically to target cells in mouse models of DFNB1 deafness, restoring hearing function and validating the approach in nonhuman primates.

This study identifies cis-regulatory elements that drive motor neuron-specific gene expression in viral vectors, showing selectivity in mice and non-human primates.

The paper uses single-cell RNA sequencing to study how transcriptional changes during neurogenesis lead to the sequential generation of distinct septal neuron types.

PESCA identifies cell-type-specific enhancers using ATAC- and single-cell RNA-sequencing to generate viral reagents for targeted gene manipulation in mammalian cells.

This paper introduces cNMF, a matrix factorization method to disentangle cell-type identity and activity programs from scRNA-Seq data, showing it improves cell type hierarchy and identifies novel activity programs.

This study shows that sensory lesioning causes microglia to eliminate synapses through ADAM10 and fractalkine signaling, revealing a neuron-to-microglia pathway for synaptic remodeling.