Shervin Tabrizi

This paper identifies molecular features of monoclonal antibodies that enhance ctDNA detection by increasing its concentration in blood.

A DNA-binding agent increases cfDNA levels in blood, improving ctDNA detection and cancer sensitivity in mice.

A nanoparticle priming agent increases cfDNA levels in blood, improving ctDNA detection sensitivity in tumor-bearing mice.

This paper introduces cNMF, a matrix factorization method to disentangle cell-type identity and activity programs from scRNA-Seq data, showing it improves cell type hierarchy and identifies novel activity programs.