The D2-mdx mouse as a preclinical model for Duchenne muscular dystrophy: a natural history study across two independent sites
Paola Mantuano, Antonietta Mele, Brigida Boccanegra, C. Tanganyika-de Winter, Davy Van De Vijver, Anne-Fleur E. Schneider, Marco Mele, Ornella Cappellari, Lisamaura Tulimiero, Sarah Engelbeen, Ernst Suidgeest, Louise van der Weerd, Annemieke M Aartsma-Rus, Annamaria De Luca, Heather Gordish‐Dressman, Maaike van Putten
This study compares the natural history of two DMD mouse models, BL10-mdx and D2-mdx, across two sites, finding distinct phenotypes and highlighting the importance of genetic background.
bioRxiv · Jul 12, 2026 · PreprintPharmacology & Toxicology