Louise van der Weerd

The D2-mdx mouse as a preclinical model for Duchenne muscular dystrophy: a natural history study across two independent sites

This study compares the natural history of two DMD mouse models, BL10-mdx and D2-mdx, across two sites, finding distinct phenotypes and highlighting the importance of genetic background.

Evaluating the Therapeutic Efficacy of Iopanoic Acid in a DMM-Induced Osteoarthritis Mouse Model and Osteochondral Lesioned Human Explants

This study evaluates iopanoic acid's therapeutic effects on osteoarthritis using mouse models and human tissue explants, showing reduced cartilage degradation and improved repair.

Therapeutic efficacy of hiMSC-derived Extracellular Vesicles from Serum-containing and Xeno-free media for osteoarthritis treatment

This study evaluates the therapeutic effects of hiEVs from different media in an OA mouse model, finding that xeno-free hiEVs reduce joint damage and promote cartilage repair.

GeneSurfer Enables Transcriptome-wide Exploration and Functional Annotation of Gene Co-expression Modules in 3D Spatial Transcriptomics Data

GeneSurfer explores and annotates gene co-expression modules in 3D spatial transcriptomics data, identifying localized transcriptome-wide co-expression patterns.

Advancing Therapeutic Solutions: Poloxamer-based Thermosensitive Injectable Hydrogels containing a Self-assembling Peptide for In situ Gelation in an Osteoarthritis Murine Model

This paper develops a poloxamer-based hydrogel with a self-assembling peptide for rapid in situ gelation and sustained drug delivery in an osteoarthritis mouse model.

Multi-scale Assessment of Brain Blood Volume and Perfusion in the APP/PS1 Mouse Model of Amyloidosis

This study assesses brain vascular structure and function in APP/PS1 mice with amyloid β plaques, finding no differences in cerebral blood volume or flow compared to wild-type controls.

Co-expression patterns of microglia markers Iba1, TMEM119 and P2RY12 in Alzheimer's disease

The paper analyzes the co-expression patterns of Iba1, TMEM119, and P2RY12 in microglia from Alzheimer's patients and controls, finding differences in marker combinations associated with disease pathology.

Iron-loading is a prominent feature of activated microglia in Alzheimer's disease patients

The paper identifies iron-accumulating microglia in Alzheimer's brains, linking iron uptake to microglial activation and disease pathology.

Post-mortem T2*- weighted MRI imaging of cortical iron reflects severity of Alzheimer’s Disease

This study shows that iron-sensitive MRI can detect AD pathology distribution patterns in post-mortem brain tissue, with EOAD showing more severe MRI changes.