Maaike van Putten

This study uses spatial transcriptomics to compare gene expression changes in brain regions of mdx and mdx4cv DMD mouse models, revealing distinct patterns linked to dystrophin isoform loss.

The paper develops four humanized DMD mouse models with specific human exon deletions to test exon skipping therapies for Duchenne muscular dystrophy.

This study uses spatial transcriptomics to evaluate exon-skipping therapies for DMD in the CNS, showing U7ex51 effectively restores full-length dystrophin isoforms in neurons.

This study compares the natural history of two DMD mouse models, BL10-mdx and D2-mdx, across two sites, finding distinct phenotypes and highlighting the importance of genetic background.

This paper introduces a novel DMD mouse model with non-uniform dystrophin expression and shows that partial dystrophin expression protects against muscle pathology.

The paper uses spatial transcriptomics in DMD mouse models to identify gene expression signatures linked to histopathological changes in skeletal muscle.

The paper develops a high-throughput method to analyze myofiber composition and identifies age- and muscle-specific patterns and disease-related changes.