MXRA8-dependent chikungunya virus infection in PDGFRα+ mesenchymal cells increases vascular permeability and facilitates hematogenous spread
Autumn C. Holmes, Yael Alippe, Deborah J. Lenschow, Michael Diamond
This study shows that MXRA8-dependent infection of PDGFRα+ mesenchymal cells by CHIKV increases vascular permeability, enabling hematogenous spread and joint swelling.
bioRxiv · Oct 8, 2026 · PreprintMicrobiology