Incidental conformational switching in an allosteric enzyme
Paul J. Sapienza, Darex Javier Vera-Rodriguez, Trevor R. Mileur, Andrew L. Lee
This study shows that yeast chorismate mutase exhibits incidental conformational switching, challenging the traditional two-state allosteric model by demonstrating decoupling between conformational state and catalytic activity.
bioRxiv · Aug 7, 2026 · PreprintBiophysics