Author

Trevor R. Mileur

University of North Carolina at Chapel HillORCID 0000-0002-4538-9764Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1 Assay:structural biology· 1 Organism:yeast· 1

Frequent Co-Authors

Andrew L. LeeiD· 2 shared Paul J. SapienzaiD· 2 shared Darex Javier Vera-RodrigueziD· 1 shared Jeffrey AubéiD· 1 shared Kelin LiiD· 1 shared Muhammad S. Khan· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 12 mutual co-author links

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2 shared papersBiophysics

Andrew L. LeeORCID

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2 papers

Recent·Most cited

Dynamic view of an allosteric intermediate in a positively cooperative dimer

Paul J. Sapienza, Trevor R. Mileur, Muhammad S. Khan, Kelin Li, Jeffrey Aubé, Andrew L. Lee

This paper stabilizes and analyzes the singly-bound intermediate of chorismate mutase to reveal that positive cooperativity arises from dynamic ensemble behavior rather than a simple two-state switch.

bioRxiv · Aug 21, 2026 · PreprintBiophysics

Incidental conformational switching in an allosteric enzyme

Paul J. Sapienza, Darex Javier Vera-Rodriguez, Trevor R. Mileur, Andrew L. Lee

This study shows that yeast chorismate mutase exhibits incidental conformational switching, challenging the traditional two-state allosteric model by demonstrating decoupling between conformational state and catalytic activity.

bioRxiv · Aug 7, 2026 · PreprintBiophysics