ZEB1 regulates BCL2 in cancer-associated fibroblasts to promote cholangiocarcinoma chemoresistance to gemcitabine and cisplatin
Ester Gonzalez‐Sanchez, Marie Vallette, Aashreya Ravichandra, Mirko Minini, Allan Pavy, Josep Amengual, Carlos Andres Roldan-Hernandez, Corentin Louis, Juan José Lozano, Isabel Fabregat, Nathalie Guedj, Valérie Paradis, Cédric Coulouarn, Lynda Aoudjehane, Laura Fouassier, Javier Vaquero
This study shows ZEB1 in cancer-associated fibroblasts regulates BCL2 to promote chemoresistance in cholangiocarcinoma, suggesting BCL2 inhibitors could enhance gemcitabine and cisplatin efficacy.
bioRxiv · Sep 10, 2025 · PreprintCancer Biology