Megan A. Cooper

This study identifies altered purinergic signaling and CD8+ T cell dysregulation in STAT3 GOF syndrome, showing partial normalization with JAK inhibitors.

This study shows ACLY supports NK cell effector functions by regulating glycolysis and histone acetylation, with acetate supplementation restoring these functions in ACLY-deficient cells.

This study tracks clonal evolution in cutaneous T-cell lymphoma using multi-omics data to identify progression-associated mutations and potential therapeutic targets.

The paper identifies rare loss-of-function variants in type I IFN immunity genes associated with severe COVID-19, particularly in younger patients with recessive inheritance.