CD8+ T cells and Humoral Immunity Influence the Development of Antibody-Dependent Enhancement: Implications for Vaccine Design
Riley S. Drake, Hasan Ahmed, Anmol Chandele, Rafi Ahmed, Kaja Murali‐Krishna, Rustom Antia
This paper develops a mechanistic model showing that intermediate antibody levels and low CD8+ T-cell immunity increase dengue disease severity, and that CD8+ T-cell responses can mitigate antibody-dependent enhancement.
bioRxiv · Mar 13, 2026 · PreprintImmunology