Rodney J. Douglas

The paper shows that the eigengene, the principal component of gene expression, maintains an invariant global spatial pattern across mouse and zebrafish brain development, suggesting evolutionary conservation and a lineage-based explanation.

The paper proposes a mechanism for axon guidance using gene expression patterns from neural stem cell lineage trees, validated through simulations and mouse brain data.

The paper shows that CA3 hippocampal neurons rapidly adapt their firing patterns in response to subthreshold synaptic input, indicating intrinsic plasticity shaped by their activity history.

The paper infers a gene regulatory network from sparse data that controls mouse cortical neurogenesis and generates distinct cortical areas through gene modulation.