Federico Brandalise

An endocannabinoid-nitric oxide signaling switch triggers reciprocal inhibitory-excitatory plasticity at dopamine neuron inputs following prenatal cannabinoid exposure

This study investigates how prenatal cannabinoid exposure affects endocannabinoid-mediated synaptic plasticity in dopamine neurons, revealing a switch to nitric oxide signaling that alters excitatory and inhibitory plasticity.

Sleep deprivation impairs information processing via dysregulation of chloride homeostasis in the prefrontal cortex

This study shows sleep deprivation impairs information processing in the prefrontal cortex by disrupting chloride homeostasis through KCC2 reduction and BDNF-TrkB signaling, which can be mitigated by bumetanide or AP synthesis blockade.

Neurogliaform cells mediate interhemispheric modulation of sensory-evoked activity in cortical pyramidal neurons

This study shows neurogliaform cells mediate interhemispheric inhibition and modulate sensory perception by affecting pyramidal neuron activity in the mouse barrel cortex.

Higher-order thalamocortical projections selectively control excitability via NMDAR and mGluRI-mediated mechanisms.

This study shows that higher-order thalamocortical projections increase excitability in L2/3 pyramidal neurons via NMDAR and mGluRI mechanisms, distinct from other inputs.

Impaired dendritic spike generation in the Fragile X prefrontal cortex is due to loss of dendritic sodium channels

The paper investigates dendritic spike generation in prefrontal cortex neurons of Fragile X mice and finds impaired sodium channel function leading to altered input-output transformation.

Conditioning by Subthreshold Synaptic Input Changes the Intrinsic Firing Pattern of CA3 Hippocampal Neurons

The paper shows that CA3 hippocampal neurons rapidly adapt their firing patterns in response to subthreshold synaptic input, indicating intrinsic plasticity shaped by their activity history.