Quirin Manz

This paper introduces a Nextflow pipeline to evaluate disease module detection methods, showing variability in results due to method, network, and seed differences.

EpiATLAS provides a comprehensive collection of human reference epigenomes to advance epigenomic research and understanding of cellular function and disease.

The paper re-evaluates epigenetic control of alternative splicing using EpiATLAS data, confirming associations between DNAm and H3K36me3 with exon inclusion and highlighting gene expression biases and epigenetic prediction of PSI values.

The paper compares differential expression analysis methods for CyTOF data, finding that median-based methods are reliable for non-zero-inflated data while methods using full distributions handle zero-inflation better but may overpredict.