Author

Alfred S.L. Cheng

Chinese University of Hong KongORCID 0000-0003-2345-6951Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 4

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Assay:whole-genome sequencing· 3 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Kevin Yuk-Lap YipiD· 3 shared C.-C. ChengiD· 2 shared Le LiiD· 2 shared Ming Fung CheungiD· 2 shared Paul B.S. LaiiD· 2 shared Savio Ho-Chit ChowiD· 2 shared Abdulrahman SalhabiD· 1 shared Adriana Redensek· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenomics

Kevin Yuk-Lap YipORCID

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4 papers

Recent·Most cited

GenomicsbioRxivPreprintJun 26, 2026

EpiATLAS - a reference for human epigenomic research

Quirin Manz, Misha Bilenky, Dennis Hecker…·Samuel A. J. R. Aparicio

EpiATLAS provides a comprehensive collection of human reference epigenomes to advance epigenomic research and understanding of cellular function and disease.

2 citations

humanChIP-seq

𝕏 PostBluesky

GenomicsbioRxivPreprintSep 16, 2024

Epigenomic analysis of hepatocellular carcinoma reveals aberrant cis-regulatory changes and dysregulated retrotransposons with prognostic potentials

C.-C. Cheng, Ming Fung Cheung, Ah Young Lee…·Danny Leung

This study identifies epigenetic changes in HCC that affect cis-regulatory elements and retrotransposons, linking them to gene dysregulation and poor prognosis.

1 citation

humanDNA methylation

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GenomicsBriefings in BioinformaticsPeer-reviewedNov 22, 2023

Accurate identification of structural variations from cancer samples

Le Li, Chenyang Hong, Jie Xu…·Kevin Yuk-Lap Yip

The paper introduces COMSV, a method for identifying structural variations in cancer samples, showing high sensitivity and specificity and detecting hundreds of novel SVs per sample.

6 citations

whole-genome sequencingstatistical model

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GenomicsGenome ResearchPeer-reviewedApr 1, 2019

New guidelines for DNA methylome studies regarding 5-hydroxymethylcytosine for understanding transcriptional regulation

Le Li, Yuwei Gao, Qiong Wu…·Kevin Yuk-Lap Yip

This study evaluates the impact of 5-hydroxymethylcytosine (5hmC) and PDR on gene expression inference using WGBS and oxWGBS data from normal and tumor tissues.

30 citations

humanwhole-genome sequencing

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