Author

Laura E. Dean

University of IowaORCID 0000-0002-5718-5435Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1

Frequent Co-Authors

Hans‐Joachim LehmleriD· 2 shared Andrea Adamcakova‐DoddiD· 1 shared Budhaditya BasuiD· 1 shared Destiny TiburcioiD· 1 shared Hui M. WangiD· 1 shared Michal J. ToborekiD· 1 shared Nicole M. BreeseiD· 1 shared Rachel F. MarekiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Hans‐Joachim LehmlerORCID

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2 papers

Recent·Most cited

NeuroscienceMolecular PsychiatryPeer-reviewedJan 31, 2026

Spatial transcriptomic profiling uncovers the molecular effects of the neurotoxicant polychlorinated biphenyls (PCBs) in the brains of adult mice

Budhaditya Basu, Nicole M. Breese, Sal Lombardi…·Snehajyoti Chatterjee

This study investigates the molecular effects of PCB exposure on brain function in mice using spatial transcriptomics and identifies disruptions in tight junction proteins and gene expression networks.

3 citationstop 2%

mousespatial transcriptomics

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Pharmacology & ToxicologybioRxivPreprintAug 1, 2025

Ramping up the Heat: Induction of Systemic and Pulmonary Immune Responses and Metabolic Adaptations in Mice

Laura E. Dean, Andrea Adamcakova‐Dodd, Hans‐Joachim Lehmler

This study shows that gradual heat exposure in mice triggers sex-specific changes in immune responses and metabolism, affecting cytokines, microbiota, and metabolites.

1 citation

mousebulk RNA-seq

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